logo Sona17th International Conference of the Society of Neuroscientists of Africalogo_Amn
Marrakesh-Morocco
April, 17-20, 2025

Symposium 14
Title: The signaling system of the neuropeptide relaxin 3/rxfp3 in cognitive and pain processes
Organizer: Monica Navarro & Olucha Bordonau (Spain)

Universitat Jaume I, Av Vicent Sos Baynat sn, Castellón, Spain
email: folucha@uji.es; monavarr@uji.es

Abstract:
The modulation of forebrain activity allows to an adaptation of the ongoing behavior to several environmental conditions. The nucleus incertus in the pontine tegmentum displays a widespread system of ascending projections to forebrain areas involved in emotional and cognitive processing.
These areas include the cingulate cortex, the hippocampus, the medial septum and the supramammillary nucleus. As the nucleus incertus contains a high concentration of the corticotropin releasing factor-receptor 1, this nucleus could play a role of an extended modulation of the forebrain function under a stress condition. Cells in the nucleus incertus produce and delivers through axon terminals the neuropeptide relaxin3 which is the ligand of the RXFP·G-protein coupled receptor.
Interference of this signaling system has an impact on the hippocampal theta rhythm associated with learning processes, disruption of anxiety, social behavior and food and alcohol intake. In this symposium, F. Olucha-Bordonau will give a general overview of the system and its evolutive meaning. M. Zahran will provide data on the effect of the alcohol withdrawal on the aggressive behavior related to relaxin3 expression in forebrain areas and the relationship to c-fos expression in these areas. M. Navarro-Sanchez will provide new data on relaxin3 activation in the retrosplenial cortex and its impact on contextual fear conditioning acquisition, retrieval and extinction. Finally, S. Scoffier will analyze the effect of interfering relaxin3/rxfp3 transmission in the anterior cingulate cortex and in the amygdala on mechanical and thermic pain. The aim of this symposium is to provide data about the feasibility of the relaxin3/RXFP3 as a potential target to treat cognitive and emotional disfunctions.

Speakers
Number
Speaker
e-mail
Title of  the communication
SP14_1
Francisco Olucha Bordonau folucha@uji.es
The evolutive meaning of the relaxin3-rxfp3 system and new ways on cognition, emotion and metabolic processing
SP14_2
Mohamed Zahran
zahran@uji.es
Peptidergic systems involved in aggressive processes after alcohol intoxication
SP14_3
Solene Escoffier
solene.escoffier@u-bordeaux.fr
Neuroanatomical basis for the anti-nociceptive role of the relaxin-3/RXFP3 peptidergic system
SP14_4
Monica Navarro-Sánchez
monavarr@uji.es
Neuropeptidergic Modulation and Neural Pathways in Contextual Fear Conditioning and Extinction: Insights from the Retrosplenial Cortex and Nucleus Incertus