17th International Conference of the Society of Neuroscientists of Africa Marrakesh-Morocco April, 17-20, 2025

Title: Molecular Mechanisms of Heavy Metal Toxicity in Neurodegenerative Diseases: Translational Medicine and the Role of Natural Antidotes
Organizer: Chinna Orish
Department of Anatomy.University of PortHarcourt.Rivers State
email: chinna.orish@uniport.edu.ng

Abstract:

Neurodegenerative diseases, marked by progressive neuronal degeneration, represent an escalating global public health crisis. Emerging evidence strongly links exposure to heavy metals like lead, mercury, cadmium, and aluminum with the onset and progression of these disorders. This symposium will examine the molecular mechanisms by which heavy metals induce neurotoxicity, emphasizing their role in the pathogenesis of neurodegenerative diseases.Heavy metal toxicity initiates a cascade of detrimental molecular events, including oxidative stress, chronic inflammation, mitochondrial dysfunction, and disrupted metal homeostasis. These processes contribute to misfolded protein accumulation,synaptic dysfunction, and neuronal cell death hallmarks of conditions such as Alzheimer's, Parkinson's, and ALS. A thorough understanding of these pathways is critical for the development of targeted therapeutic interventions. Translational medicine is essential in transforming laboratory research into clinical applications, offering new hope for those affected by neurodegenerative diseases. Advances in understanding heavy metal-induced neurotoxicity have led to innovative diagnostic tools, biomarkers, and therapeutic strategies. Approaches like nanotechnology, gene therapy, and pharmacological interventions show promise in counteracting the neurotoxic effects of heavy metals, potentially slowing or halting disease progression ting agents exhibit neuroprotective properties by scavenging free radicals, modulating inflammation, and enhancing metal excretion. These natural compounds provide valuable insights for developing safe, adjunctive therapies. This presentation will synthesize the current understanding of the molecular mechanisms underlying heavy metal toxicity in neurodegenerative diseases. It will also highlight the translational potential of recent scientific advancements and the role of natural antidotes in creating effective treatment strategies. By elucidating these complex interactions, this symposium aims to contribute to the development of targeted interventions that could significantly alleviate the global burden of neurodegenerative diseases.

Speakers

Number	Speaker	e-mail	Title of  the communication
SP18_1	Mohamed Salama	mohamed.salama@aucegpt.edu	Towards a holistic understanding of neurodegenerative diseases
SP18_2	Elvis Cuevas	elcuevas@utmb.edu	The influence of estrogen in Alzheimer’s disease is linked to neurovascular unit responses
SP18_3	Chinna Orish	chinna.orish@uniport.edu.ng	Rice bran extract ameliorates metal mixture- induced cerebral cortex toxicity. Possible role of Nrf-2/HMOX-1/BDNF signalling pathways.
SP18_4	Iliyasu Musa Omoyine	iliyasu.mo@ksu.edu.ng	The role of natural substances against lead-induced neuronal degeneration and cognitive deficits in a rat model