 17th
International Conference of the Society of Neuroscientists of Africa Marrakesh-Morocco April, 17-20, 2025 |
MNS-sponsored
Symposium 2
Symposium 2
Title: Serotonergic Modulation and Neurochemical Pathways:
Implications for Antidepressant Efficacy, Epilepsy, and Neurotoxicity
Organizer: De Deurwaerdere & Bamidele Victor Owoyele
Universuty of Bordeaux; CNRS UMR 5287; 2 rue du Docteur Hoffmann Martinot, 33076 Bordeaux Cedex; France
email: pdeurwaer@gmail.com; owoyele@unilorin.edu.ng
Abstract:
| This symposium will showcase
research from young researchers and leading experts exploring the role
of serotonergic receptors in various neurological and psychiatric
conditions, including depression, epilepsy, and the impact of
neurotoxins on brain function. 1. Soukaina Es-Safi (University of Bordeaux) will discuss the rapid antidepressant efficacy of 5-HT4 receptors, focusing on the neuro-plasticity mechanisms that could accelerate the onset of antidepressant action. Her work, conducted as part of her PhD, emphasizes novel therapeutic targets for rapid-acting antidepressant action. 2. Sabrine Ben Slimen (University of Sfax) will present findings on how pesticides, individually or in combination, affect brain monoamine function in rats. Her research addresses critical concerns about environmental toxins and their impact on neuropsychiatric health, using rodent models to explore the underlying neurochemical disruptions. 3. Patrick Oluwole Abolarin: (University of Ilorin/Chrisland University) will present his findings on how tannic acid administration influenced the brain serotonin availability and depressive like behaviour in rats. His work, which was conducted as part of his recently defended Ph.D. thesis identify a pivotal role for interventions using tannic acid in glyphosate-based pesticide induced neurotoxicity and spread awareness on the toxicity pesticides. 4. Professor Philippe De Deurwaerdère (University of Bordeaux) will lead a discussion on the neurochemical responses of brain-wide neurotransmitter systems to psychedelic drugs and the role of 5-HT2A receptor antagonism. His extensive work in neurotransmitter analysis bridges basic and clinical research, offering insight into potential psychiatric applications of psychedelics. 5. Professor Giuseppe Di Giovanni (University of Magna Graecia) will present his research on the modulation of GABAA receptor tonic inhibition and GAT1 function by 5-HT2A receptors, with a focus on absence epilepsy. His groundbreaking studies propose new therapeutic targets for epilepsy and related neuropsychiatric comorbidities. This symposium promises to deepen our understanding of serotonergic modulation across different neurological disorders and offer novel perspectives on therapeutic interventions. |
Speakers
| Number |
Speaker |
e-mail |
Title
of the communication |
| SP2_1 |
Soukaina Es-Safi | soukaina.es-safi@u-bordeaux.fr |
5-HT4 receptors of the medial Prefrontal Cortex impair the induction of a long-term potentiation within the Dentate Gyrus |
| SP2_2 |
Sabrine Ben Slimen |
sabrinebenslimene1@gmail.com |
Effect of pesticides alone or combined on monoamines and behavior in rats |
| SP2_3 |
Patrick Oluwole
Abolarin |
wolexpatrick@gmail.com |
Reversibility of
Glyphosate-induced serotonin depletion and depressive-like behaviour in
mice: Tannic acid intervention study |
| SP2_4 |
Philippe
De Deurwaerdere |
pdeurwaer@gmail.com |
Brain wide neurochemical analysis of neurotransmitters in response to psychedelic drugs and 5-HT2A receptor antagonist |
| SP2_5 | Giuseppe
Di Giovanni |
giuseppe.digiovanni@unicz.it |
The 5 HT2A receptor modulation of GABAA Receptor tonic Inhibition and GAT1 function implication for Absence Epilepsy |