 17th
International Conference of the Society of Neuroscientists of Africa Marrakesh-Morocco April, 17-20, 2025 |
Symposium
3
Title: Emerging effectors in neurodegeneration: from preclinical
to clinical models
Organizer: Ines Elbini & Rym Benkhalifa
Institut Pasteur de Tunis, Tunisia
email: ines.bini@pasteur.tn & rymbkh@gmail.com
Abstract:
|
This symposium
explores the impact of emerging
effectors such as ion channels, receptors, and cytokines on
neurodegeneration
within preclinical and clinical models. A particular emphasis will be
placed on
the underlying pathophysiological mechanisms driving these processes.
The
symposium will be chaired by a panel of scientists from the Institut
Pasteur of
Tunis (IPT), Tunisia, and UM6P, Morocco. Dr. Rym Benkhalifa will
elucidate the
role of Kv3.1 potassium channels in specific pathophysiological
conditions and
recount the process of investigating this channel within the context of
her
research team's work. Dr. Meriam Belghith will tackle the practical
challenges
in understanding the molecular mechanisms of neuroinflammation, a
critical
aspect of neurodegeneration. Miss Nour-elhouda Neili will present her
research
on the role of ion channels in Parkinson's disease using induced
pluripotent
stem cell (iPSC)-derived dopaminergic neurons as a model system. Her
work aims
to elucidate how dysregulation of these channels contributes to
neuronal
dysfunction, providing insights into potential therapeutic
interventions.
Finally, Dr. Mohamed Taha Moutaoufik from UM6P will explore systems
biology
approaches to understand mitochondrial functions and their implications
in
neurodegenerative diseases, with a particular focus on Parkinson's
disease. Youssef Anouar "will
describe the discovery of a new enzyme belonging to the selenoprotein
family which plays an essential role in the protection of dopaminergic
neurons and how his work led to the development of a new therapeutic
candidate for this disease.
Together, these presentations will offer a comprehensive overview of emerging effectors that could serve as potential targets for future therapeutic strategies, utilizing either natural or chemical molecules. This symposium aims to provide fresh insights into neurodegenerative disease management by highlighting innovative approaches to counteract the pathophysiological mechanisms at play. |
Speakers
| Number |
Speaker |
e-mail |
Title
of the communication |
| SP3_1 |
Rym Benkhalifa |
rymbkh@gmail.com | When the secondary role plays its full part: the story of the Kv3.1 channel in neuropathologies. |
| SP3_2 |
Meriam Belghith | belghith.meriam@gmail.com | Adaptive immune cells in the cerebrospinal fluid of neuroinflammatory disorders: a comparative study between neuro-Behçet and Multiple Sclerosis |
| SP3_3 |
Nour-elhouda Neili | neilinourelhouda1@gmail.com |
Targeting Ion Channels in
Parkinson's Disease: Insights from iPSC-Derived Dopaminergic Neurons |
| SP3_4 |
Mohamed
Moutaoufik |
mohamed.moutaoufik@um6p.ma |
Decoding Mitochondrial Interactomes: Insights into Neurodegenerative Disease Mechanisms |
| SP3_5 | Youssef Anouar | Youssef.Anouar@univ-rouen.fr |
Role of a selenoprotein in the pathophysiology of PD: therapeutic application after intranasal administration |